A Profile of Headache Disorders in Pakistan: Prevalence and Psychological Comorbidities

Abstract

Objective: To explore prevalence of headache disorders and its psychological associations in Pakistan.

Study design: It is a retrospective study.

Place and duration of study: The study was conducted in The Neurocounsel, Islamabad between the year 2017 and 2023.

Material and Methods: 514 participants, who sought treatment at a private clinic in Islamabad from all over Pakistan, participated in this retrospective research. Hit-6 and MIDAS were used for headache severity and extent of disability, HAM-A and HAM-D were applied for anxiety and depression respectively. Athen’s sleep questionnaire was administered for insomnia. After these assessments, the frequencies and descriptives were calculated.  

Results: Primary headache was reported by 63.7% of the patients, with migraine being the most common (31.9%), followed by chronic daily headache (23.2%). Secondary headache was identified in only 3.1% of the sample. 33.3% people did not meet any criteria so were categorized as Not Otherwise Specified (NOS). Women constituted about 2/3rd of patients in almost all of the headache types.

Conclusion: Primary headache is more common, and within it, migraine is the predominant type. Anxiety, depression and insomnia were also comorbid among the sample, proving that headache is not only a physiological problem but psychological issues also co-occur with it. 

Keywords: Headache, Migraine, Chronic daily headache, Secondary headache

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References

Gobel, H. (n.d.). The International Classification of Headache Disorders - ICHD-3. ICHD-3.

Robbins, M. S. (2021). Diagnosis and Management of Headache. JAMA, 325(18), 1874.

Benoliel, R., Svensson, P., Evers, S., Wang, S.-J., Barke, A., Korwisi, B., Rief, W., & Treede, R.-D. (2019). The IASP classification of chronic pain for ICD-11. PAIN, 160(1), 60–68.

Caponnetto, V., Deodato, M., Robotti, M. et al. Comorbidities of primary headache disorders: a literature review with meta-analysis. J Headache Pain 22, 71 (2021).

Steiner TJ, Stovner LJ, Jensen R et al (2020) Migraine remains second among the world’s causes of disability, and first among young women: findings from GBD2019. J Headache Pain 21:137

Patel UK, Malik P, Sheth R et al (2019) Fibromyalgia and Myositis Linked to Higher Burden and Disability in Patients with Migraine. SN Compr Clin Med 1:882–890

Stovner LJ, Nichols E, Steiner TJ, Abd-Allah F, Abdelalim A, Al-Raddadi RM et al (2018) Global, regional, and national burden of migraine and tension-type headache, 1990–2016: a systematic analysis for the global burden of disease study 2016. Lancet Neurol 17(11):954–976

Bolay H, Gul A, Baykan B (2020) COVID-19 is a real headache! Headache. 60:1415–1421

Uygun, Ö., Ertaş, M., Ekizoğlu, E. et al. Headache characteristics in COVID-19 pandemic-a survey study. J Headache Pain 21, 121 (2020).

Nowaczewska, M., Wiciński, M., Osiński, S., & Kaźmierczak, H. (2020). The Role of Vitamin D in Primary Headache–from Potential Mechanism to Treatment. Nutrients, 12(1), 243.

Diener, H.-C., Dodick, D., Evers, S., Holle, D., Jensen, R. H., Lipton, R. B., Porreca, F., Silberstein, S., & Schwedt, T. (2019). Pathophysiology, prevention, and treatment of medication overuse headache. The Lancet Neurology, 18(9), 891–902.

Wöber C, Wöber-Bingöl Ç, Uluduz D, Aslan TS, Uygunoglu U, Tüfekçi A et al (2018) Undifferentiated headache: broadening the approach to headache in children and adolescents, with supporting evidence from a nationwide school-based cross-sectional survey in Turkey. J Headache Pain 19(1):18

Philipp, J., Zeiler, M., Wöber, C. et al. Prevalence and burden of headache in children and adolescents in Austria – a nationwide study in a representative sample of pupils aged 10–18 years. J Headache Pain 20, 101 (2019).

Burch, R., Rizzoli, P., & Loder, E. (2020). The prevalence and impact of migraine and severe headache in the United States: Updated age, sex, and socioeconomic‐specific estimates from government health surveys. Headache: The Journal of Head and Face Pain, 61(1), 60–68.

Yamani, N., Olesen, J. New daily persistent headache: a systematic review on an enigmatic disorder. J Headache Pain 20, 80 (2019).

Ullah, Z., Awan, I., Usman, A., Mahmood, K., Lalchand, & Khan, M. F. (2022). Prevalence of Depression in Migraine Patients: A Multicentre Cross-Sectional Study from Pakistan. Pakistan Journal of Medical and Health Sciences, 16(9), 566–568.

Psychiatric Illnesses, Somatic Complaints, and Treatments in a Tertiary Care Hospital in Khyber Pakhtunkhwa, Pakistan: A Cross-Sectional Study

Jafari, E., Hajar Kazemizadeh, Mansoureh Togha, Haghighi, S., Salami, Z., Shahamati, D., Fahimeh Martami, Vali Baigi, & Farnaz Etesam. (2022). The influence of anxiety and depression on headache in adolescent migraineurs: a case-control study. Expert Review of Neurotherapeutics, 22(11-12), 1019–1023.

Sugiura, Y. Longitudinal Relationships Between Anxiety, Depression, Repetitive Negative Thinking and Headache Among Non-clinical Students After One Week and One Month. J Cogn Ther 16, 237–265 (2023).

Ishaq Abu‐Arafeh. (2023). Headache and Psychological Comorbidities: An Appraisal of the Evidence. Journal of Clinical Medicine, 12(7), 2683–2683.

Titlić, M. (2023). Tension - Type Headache in Clinical Practice. Archives of Psychiatry Research, 59(1), 149–150.

Herekar A, Herekar AA, Ahmad A, Uqaili UL, Ahmed B, Effendi J, et al. The burden of headache disorders in Pakistan: methodology of a population-based nationwide study, and questionnaire validation. Journal of Headache and Pain [Internet]. 2013 Aug 22;14(1).

Murtaza, M., Kisat, M., Haroon, D., & Sonawalla, A. (2009). Classification and clinical features of headache disorders in Pakistan: a retrospective review of clinical data. PLOS ONE, 4(6), e5827.

Paredes, S., Cantillo, S., Candido, K. D., & Knezevic, N. N. (2019). An Association of Serotonin with Pain Disorders and Its Modulation by Estrogens. International Journal of Molecular Sciences, 20(22), 5729.

Konno S, Meyer JS, Margishvili GM, Rauch RA, Haque A. Transformed migraine is a cause of chronic daily headaches. Headache: The Journal of Head and Face Pain [Internet]. 1999 Feb 1;39(2):95–100.

Bihldorff, J. P., King, S. H., & Parnes, L. R. (1971). PSYCHOLOGICAL FACTORS IN HEADACHE. Headache: The Journal of Head and Face Pain.

Merikangas, K. R., Stevens, D., & Angst, J. (1993). Headache and personality: Results of a community sample of young adults. Journal of Psychiatric Research, 27(2), 187–196.

Aaseth, K., Grande, R. B., Leiknes, K. A., Benth, J. Š., Lundqvist, C., & Russell, M. B. (2011). Personality traits and psychological distress in persons with chronic tension-type headache. The Akershus study of chronic headache. Acta Neurologica Scandinavica, 124(6), 375–382.

Panerai, A. E. (2012). Pain stress and headache. Neurological Sciences, 33(S1), 1–3.

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