Keywords
Abstract
Objective: To evaluate pulmonary function in diabetic patients with Chronic Obstructive Pulmonary Disease (COPD) and asthma and to investigate the potential correlation between the duration of diabetes and the severity of spirometry abnormalities.
Study design: It was a Cross-Sectional Comparative Study.
Place and duration of study: The study was conducted at Integrated Medical Care Hospital Lahore, over a 4 month of duration from October 1, 2024, to January 2025.
Material and Methods: In this study, 88 subjects underwent clinical and biochemical glycemic control and spirometry assessments at Integrated Medical Care Hospital Lahore, over a 4 month of duration.
Results: Total of 88 patients (mean age 55.1 years) were included. Diabetic asthma and COPD patients had more compromised FVC (1.5 ± 0.3 L vs. 2.8 ± 0.4 L, p < 0.05) and FEV₁ (1.0 ± 0.2 L vs. 2.5 ± 0.3 L, p < 0.05) compared to the non-diabetics, with a less favorable FEV₁/FVC ratio (p = 0.002) reflecting increased airflow limitation Chi-square analysis revealed a significant relation between diabetes and obstructive/restrictive spirometric patterns (p = 0.005), but diabetic groups had a more severe disease (p = 0.038). Linear regression also validated that there was a significant decrease in lung function with prolonged disease duration (p < 0.002). The results indicate the adverse effect of diabetes on lung function, supporting early screening and combination disease management.
References
Ho T-W, Huang C-T, Ruan S-Y, Tsai Y-J, Lai F, Yu C-J. Diabetes mellitus in patients with chronic obstructive pulmonary disease-The impact on mortality. PLoS One. 2017;12(4):e0175794.
Brashier BB, Kodgule R. Risk factors and pathophysiology of chronic obstructive pulmonary disease (COPD). J Assoc Physicians India. 2012;60(Suppl):17-21.
American Lung Association Epidemiology and Statistics Unit. Trends in COPD (Chronic Bronchitis and Emphysema): Morbidity and Mortality. 2013.
Allinson JP, Hardy R, Donaldson GC, Shaheen SO, Kuh D, Wedzicha JA. The presence of chronic mucus hypersecretion across adult life in relation to chronic obstructive pulmonary disease development. American journal of respiratory and critical care medicine. 2016;193(6):662-72.
Rajvanshi N, Kumar P, Goyal JP. Global initiative for asthma guidelines 2024: an update. Indian pediatrics. 2024;61(8):781-6.
Sinyor B, Perez LC. Pathophysiology of asthma. StatPearls [Internet]: StatPearls Publishing; 2023.
Chapman DG, Irvin CG. Mechanisms of airway hyper-responsiveness in asthma: the past, present and yet to come. Clin Exp Allergy. 2015;45(4):706-19.
Petersmann A, Müller-Wieland D, Müller UA, Landgraf R, Nauck M, Freckmann G, et al. Definition, classification and diagnosis of diabetes mellitus. Experimental and Clinical Endocrinology & Diabetes. 2019;127(S 01):S1-S7.
Meo SA. Significance of spirometry in diabetic patients. International Journal of Diabetes Mellitus. 2010;2(1):47-50.
Visca D, Pignatti P, Spanevello A, Lucini E, La Rocca E. Relationship between diabetes and respiratory diseases—Clinical and therapeutic aspects. Pharmacological Research. 2018;137:230-5.
van de Hei SJ, Flokstra-de Blok BMJ, Baretta HJ, Doornewaard NE, van der Molen T, Patberg KW, et al. Quality of spirometry and related diagnosis in primary care with a focus on clinical use. npj Primary Care Respiratory Medicine. 2020;30(1):22.
Langan RC, Goodbred AJ. Office Spirometry: Indications and Interpretation. Am Fam Physician. 2020;101(6):362-8.
Graham BL, Steenbruggen I, Miller MR, Barjaktarevic IZ, Cooper BG, Hall GL, et al. Standardization of spirometry 2019 update. An official American thoracic society and European respiratory society technical statement. American journal of respiratory and critical care medicine. 2019;200(8):e70-e88.
Mishra G, Dhamgaye T, Tayade B, Fuladi A, Amit S, Mulani J. Study of Pulmonary Function Tests in Diabetics with COPD or Asthma. Applied cardiopulmonary pathophysiology: ACP. 2012;16:299-308.
Varmaghani M, Dehghani M, Heidari E, Sharifi F, Moghaddam SS, Farzadfar F. Global prevalence of chronic obstructive pulmonary disease: systematic review and meta-analysis. East Mediterr Health J. 2019;25(1):47-57.
Scott HA, Ng SH, McLoughlin RF, Valkenborghs SR, Nair P, Brown AC, et al. Effect of obesity on airway and systemic inflammation in adults with asthma: a systematic review and meta-analysis. Thorax. 2023;78(10):957-65.
Su J, Li M, Wan X, Yu H, Wan Y, Hang D, et al. Associations of diabetes, prediabetes and diabetes duration with the risk of chronic obstructive pulmonary disease: A prospective UK Biobank study. Diabetes, Obesity and Metabolism. 2023;25(9):2575-85.
Kinney GL, Black-Shinn JL, Wan ES, Make B, Regan E, Lutz S, et al. Pulmonary Function Reduction in Diabetes With and Without Chronic Obstructive Pulmonary Disease. Diabetes Care. 2014;37(2):389-95.
Zhang R-H, Cai Y-H, Shu L-P, Yang J, Qi L, Han M, et al. Bidirectional relationship between diabetes and pulmonary function: a systematic review and meta-analysis. Diabetes & Metabolism. 2021;47(5):101186
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