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Abstract
Introduction: In vitro fertilisation utilises a variety of techniques. After their first IVF cycle, those who were treated with micro-dosing or GnRH antagonist protocols, which were thought to be ineffective, will be compared to people who were treated with lengthy GnRH protocols and had poor ovarian responses and low IVF cycle egg yields.
Materials and Methods: A retrospective cohort study was carried out by KRL Hospital's Obstetrics and Gynecology Department from September 2014 to February 2019. It was determined that patients who were treated with IVF's first cycle and found to be poor responders after ovarian stimulation needed micro-dose flare-up (Group 1), GnRH antagonist (Group 2), and prolonged GnRH agonist (Group 3). (Group 3: 77 patients).
Results: The basal FSH levels in Group 3 were much lower than those in the other groups (p0.05). Metaphase II oocyte counts were similar across the groups 1, 2; however, the mean AFC of the group 3 was much higher than that of either of the other groups (p0.05). Group 3 had greater clinical pregnancy rates than groups 1 and 2 (22,9% vs. 13-7%) and 14-44 percent, however the difference was not statistically significant. The live birth rate in Group 3 was considerably greater than in the other groups (21.4 percent) (9.7 percent and 10.3 percent , respectively; p0.05).
Conclusion: Poor responders undergoing IVF may have the option of a long protocol. The presence of ovarian reserve markers is critical for the success of IVF in women who have had difficulty conceiving naturally.
Key Words: Poor responder, micro-dose flare-up, GnRH antagonist, long protocol, IVF, pregnancy outcomes.